Great question!
To me the biggest thing is preparation. Follow a consistent logging strategy which is something I wrote about
here. Make sure to prepare as much as possible. Observability tools in your production environment so you have a lifeline to fallback to.
Once you have these tools in place you make a metal switch. They make debugging small issues in production so easy you can often solve problems directly there. Since the modern production environments are so HUGE it's often hard or impossible to reproduce these things locally.